When Papa Smurf (John Goodman) is mysteriously taken by evil wizards, Razamel and Gargamel, Smurfette (Rihanna) leads the Smurfs on a mission into the real world to save him. With the help of new friends, the Smurfs must discover what defines their destiny to save the universe.

Smurfs features an all-star voice cast including Rihanna, James Corden, Nick Offerman, JP Karliak, Daniel Levy, Amy Sedaris, Natasha Lyonne, Sandra Oh, Octavia Spencer, Nick Kroll, Hannah Waddingham, Alex Winter, Maya Erskine, Billie Lourd, Xolo Maridueña, Marshmello, with Kurt Russell and John Goodman.